Most methods of treatment of psoriasis are aimed at the work of immune cells, the root cause of the disease. However, their use is somewhat limited by various side effects associated with the large-scale effects of drugs on the patient’s immune system.
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Studies of American scientists have shown that the proliferation of cell proliferation is a promising target for targeted therapy for skin diseases that are characterized by hyperproliferation of skin cells, such as for example, psoriasis.
The research team demonstrated in a mouse model that inhibiting glucose transport can be a safe and effective treatment for such diseases. The actively dividing cells, like those that underlie the pathogenesis of psoriasis, depend heavily on glucose, which is necessary for their growth. Scientists have managed to reduce hyperproliferation and skin inflammation by inhibiting glucose transport. Their results were recently published in Nature Medicine.
“This study is a window for the development of new methods of treating various hyperproliferative skin diseases, oriented to their metabolic features. Also our results give a deeper understanding of the changes in skin metabolism in response to physiological stressors, “the authors of the work write in the annotation.
If the results of their research are repeated on the human model, we can soon expect the development of new methods of treatment for patients with severe skin pathologies, including psoriasis. Recent studies have shown that people with psoriasis are at increased risk for developing other inflammatory diseases, such as rheumatoid arthritis, diabetes, Crohn’s syndrome, lupus, irritable bowel syndrome, and depression and obesity.